This course builds a coherent framework for understanding human biology from molecules to organ systems. It develops scientific thinking and data literacy while covering cell structure and function, biomolecules, membranes and transport, enzymes and metabolism, and energy flow with ATP. It links tissues to organ-level physiology, emphasizing homeostasis, feedback, and core mechanisms in circulatory, respiratory, digestive, renal, nervous, endocrine, immune, musculoskeletal, integumentary, and reproductive systems, including gas exchange and circulation fundamentals. Foundations in Mendelian and molecular genetics, gene regulation and variation, and evolutionary principles are integrated with quantitative skills for rates, proportions, and graph interpretation.