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Quick Reflection: ADME (in your words)

You’ve just learned a big idea: what the body does to a drug can be broken into four steps—A D M E. A short reflection helps your brain “save” the concept, not just recognize it.

1) Summarize ADME using the analogy

Use the analogy from the lesson (the one where the drug is like something moving through a system—like a package, traveler, or delivery route).

• In 2–4 sentences, describe what Absorption means in the analogy.
• In 2–4 sentences, describe what Distribution means in the analogy.
• In 2–4 sentences, describe what Metabolism means in the analogy.
• In 2–4 sentences, describe what Excretion means in the analogy.

Optional helpful starter (use or ignore):

• “In this analogy, absorption is like…”
• “Distribution is like…”
• “Metabolism is like…”
• “Excretion is like…”

2) Two real-life factors that change metabolism or excretion

List two real-life factors (things that can happen in real bodies, real days) that would make a drug get broken down or cleared out faster or slower.

For each factor, write:

• Factor:
• Which part it affects (metabolism or excretion):
• How it changes it (faster/slower):

3) One sentence: PK exposure problem vs PD sensitivity/target problem

Write one single sentence that clearly separates these ideas:

• PK (pharmacokinetics) = “exposure problem” (how much drug gets where it needs to go)
• PD (pharmacodynamics) = “sensitivity/target problem” (what the drug does once it gets there)

Sentence template (use or ignore):

• “If the issue is PK, then…, but if the issue is PD, then….”

Final self-check

• What is one misconception I had that is now corrected?

Tiny takeaway

If you can explain ADME with the analogy and separate PK vs PD in one clean sentence, you’re not memorizing—you’re thinking like a pharmacology pro.